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Results indicated erosive IMPA most commonly affected the carpal joints of middle-aged small-breed dogs.

Bell's palsy is an idiopathic facial nerve paralysis, which occurs without evidence of infection, reduced thryroid function, or injury. In a September 2017 article by a team of Italian veterinary blood specialists, they studied 7,414 dogs, including 103 cavalier King Charles spaniels, to determine the potential sensitization risk to dogs receiving blood transfusions consisting of the Dog Erythrocyte Antigen (DEA) 1 blood group.

Aortic thromboembolism (femoral artery occlusion) is a condition which results from a blood clot dislodging within the aorta, leading to the interruption of blood flow to tissues served by that portion of the aorta, which include the legs, kidneys, intestines, and brain.

Aortic thromboembolism is rare in other breeds and is not clinically important in most dogs because of adequate collateral circulation.

Dilated cardiomyopathy (DCM) is a disease in which the heart muscle weakens and does not function properly in order to to pump blood adequately, leading to poor circulation.

This is called a loss of "myocardial contractility".

Arthritis is a multifactorial disease, primarily genetic but often exacerbated by the dog's diet and exercise levels.

Arthritis often is secondary to a joint abnormality such as a ligament rupture or patellar luxation.

Of 10,143 cavaliers in the study, 245 were diagnosed with osteoarthritis.

The 13 affected dogs had erosive lesions in their carpal joints.

The estimated median synovial fluid lymphocyte count for dogs with erosive IMPA was significantly greater than that for dogs with nonerosive IMPA.

Following a second transfusion of DEA 1 positive blood, a dog which is highly sensitized to DEA 1 positive may develop an acute reaction, including fever, pigmenturia, and lethargy, and its packed cell volume (PCV) will not rise as expected.

Death may result from such a mis-matched second transfusion. In the 2017 Italian study, they found that CKCSs were among the few breeds having the highest percentage likelihood to become sensitized (25.0%) following the first mis-matched transfusion, and that cavaliers also were among the breeds having the highest risk (6.2%) of an acute transfusional reaction following a second such transfusion.

Of 10,143 cavaliers in the study, 245 were diagnosed with osteoarthritis.

The 13 affected dogs had erosive lesions in their carpal joints.

The estimated median synovial fluid lymphocyte count for dogs with erosive IMPA was significantly greater than that for dogs with nonerosive IMPA.

Following a second transfusion of DEA 1 positive blood, a dog which is highly sensitized to DEA 1 positive may develop an acute reaction, including fever, pigmenturia, and lethargy, and its packed cell volume (PCV) will not rise as expected.

Death may result from such a mis-matched second transfusion. In the 2017 Italian study, they found that CKCSs were among the few breeds having the highest percentage likelihood to become sensitized (25.0%) following the first mis-matched transfusion, and that cavaliers also were among the breeds having the highest risk (6.2%) of an acute transfusional reaction following a second such transfusion.

See these veterinary reports for details about this disorder in cavaliers.